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Notably, the highest dose tested (54 mg) showed increased gastrointestinal event frequency compared to lower doses, suggesting a dose-relationship for this effect category

Yang DT, Robetorye RS, Rodgers GM

Testosterone replacement therapy (TRT) is an option we consider for patients who have both symptoms and laboratory evidence of low testosterone levels

TIming to full effects: 3-6 months

The relationships between symptom improvement and putative protective enzymes remained significant also after controlling for body mass index, sex, duration of SAD, smoking, concurrent psychotropic medication, and the proportion of lymphocytes to monocytes